stimulant
Mefedrona dosage 2026: safe ranges by route and weight.
Mefedrona has 3 documented routes of administration. The most common is oral. Always start at the lowest dose range and wait the full onset window before redosing.
Dose ranges by route.
Oral
- Umbral
- 50 mg
- Ligera
- 75–150 mg
- Común
- 150–225 mg
- Fuerte
- 225–350 mg
- Pesada
- 350 mg
Esnifado
- Umbral
- 15 mg
- Ligera
- 30–60 mg
- Común
- 60–120 mg
- Fuerte
- 120–175 mg
- Pesada
- 175 mg
Rectal
- Umbral
- 30 mg
- Ligera
- 50–100 mg
- Común
- 100–175 mg
- Fuerte
- 175–250 mg
- Pesada
- 250 mg
| Vía | Umbral | Ligera | Común | Fuerte | Pesada |
|---|---|---|---|---|---|
| Oral | 50 mg | 75–150 mg | 150–225 mg | 225–350 mg | 350 mg |
| Esnifado | 15 mg | 30–60 mg | 60–120 mg | 120–175 mg | 175 mg |
| Rectal | 30 mg | 50–100 mg | 100–175 mg | 175–250 mg | 250 mg |
Empieza por abajo. Cuerpo, tolerancia y mezclas lo cambian todo.
Duration timeline.
Oral
total ~ 510 min- Inicio
- 30–60 min
- Pico
- 60–120 min
- Bajada
- 60–90 min
- Resaca
- 2–4h
Esnifado
total ~ 405 min- Inicio
- 5–15 min
- Pico
- 30–60 min
- Bajada
- 45–90 min
- Resaca
- 2–4h
Rectal
total ~ 475 min- Inicio
- 10–25 min
- Pico
- 60–120 min
- Bajada
- 60–90 min
- Resaca
- 2–4h
Bodyweight quick formula
For a 70 kg adult, divide the total mg dose by 70 to get your mg/kg ratio. Most published ranges assume this reference weight. If you weigh significantly less, reduce proportionally; significantly more does not always mean linearly higher doses.
Related pages
FAQ.
- What is a safe Mefedrona dose?
- A "safe" dose depends on body weight, tolerance, set and setting. Start at the threshold or light range for your chosen route and do not redose until onset is complete.
- How do I calculate Mefedrona dose by weight?
- For substances where bodyweight matters: divide the mg amount by your weight in kg to get the mg/kg ratio. Most common dose data assumes a 70–80 kg adult.
- What happens if I take too much Mefedrona?
- Exceeding the "heavy" range significantly increases risk of adverse effects, medical emergency, or overdose. Harm reduction starts with knowing the ranges.
- How long does Mefedrona last?
- Duration varies by route. The timeline section below shows onset, peak, offset and after-effects for each route.
- Can I mix Mefedrona with other substances?
- Many combinations are dangerous. Check the interaction checker tool before combining anything. Never combine on a first experience.
- Is Mefedrona dosage the same for all routes?
- No. Bioavailability differs significantly by route — intranasal and IV routes typically require lower doses than oral for equivalent effect.
- Should I weigh my Mefedrona dose?
- Always. A milligram scale (0.001g precision) is essential for most substances. Volumetric dosing with a solvent is the gold standard for sub-10mg doses.