Comparison
MDMA vs Mefedrone.
Side-by-side comparison of MDMA and Mefedrone — dosage, effects, duration, legal status, and key harm reduction considerations.
- CategoryMDMAempathogenMefedronestimulant
- Chemical classMDMAsubstituted-amphetamineMefedronecathinone
- Common doseMDMA75–125 mgMefedrone150–225 mg
- Peak durationMDMA90–150 minMefedrone60–120 min
- Primary positivesMDMAEuphoria, Emotional warmth and openness, Increased empathyMefedroneCalore empatogeno, tipo MDMA a dosi basse, Euforia stimolante, Loquacità e disinvoltura sociale
- Primary negativesMDMAJaw clenching (bruxism), Dehydration or, conversely, hyponatremia from overhydration, Hyperthermia in warm environmentsMefedroneCraving forte, schema binge in una sessione, Vasocostrizione (mani fredde, dita bluastre), Mucosa nasale rovinata se sniffato ripetutamente
- Legal (DE)MDMAillegalMefedroneprohibited
- Legal (NL)MDMAillegal-toleratedMefedroneschedule-2
- Legal (US)MDMAschedule-1Mefedroneschedule-1
- Legal (UK)MDMAclass-aMefedroneclass-b
| MDMA | Mefedrone | |
|---|---|---|
| Category | empathogen | stimulant |
| Chemical class | substituted-amphetamine | cathinone |
| Common dose | 75–125 mg | 150–225 mg |
| Peak duration | 90–150 min | 60–120 min |
| Primary positives | Euphoria, Emotional warmth and openness, Increased empathy | Calore empatogeno, tipo MDMA a dosi basse, Euforia stimolante, Loquacità e disinvoltura sociale |
| Primary negatives | Jaw clenching (bruxism), Dehydration or, conversely, hyponatremia from overhydration, Hyperthermia in warm environments | Craving forte, schema binge in una sessione, Vasocostrizione (mani fredde, dita bluastre), Mucosa nasale rovinata se sniffato ripetutamente |
| Legal (DE) | illegal | prohibited |
| Legal (NL) | illegal-tolerated | schedule-2 |
| Legal (US) | schedule-1 | schedule-1 |
| Legal (UK) | class-a | class-b |
Key harm-reduction difference
MDMA and Mefedrone differ most in their risk profiles and durations. Always research each independently before any session. If you are choosing between them based on safety alone, consult the full profiles and the interaction checker for any combinations you may be planning.
Related pages
FAQ.
- Is MDMA stronger than Mefedrone?
- "Stronger" depends on the metric. Compare dose ranges, subjective intensity, and duration side by side above. Always factor in individual tolerance.
- Can I combine MDMA and Mefedrone?
- Check the interaction checker for this specific pair. Many combinations carry serious risk even at low doses.
- Which lasts longer, MDMA or Mefedrone?
- Duration varies by route. See the comparison table above for peak and total duration by the most common route.
- MDMA vs Mefedrone: which is safer?
- Neither substance is "safe" in absolute terms. Harm is a function of dose, setting, purity, and individual factors. The comparison above covers the key risk differences.
- Are MDMA and Mefedrone in the same drug class?
- See the category and chemical class rows above. Substances in different classes often have very different risk profiles even if subjective effects overlap.
- Is MDMA legal where Mefedrone is?
- Legal status is substance- and jurisdiction-specific. See the legal status section for key countries.
- Where can I get harm reduction info for MDMA and Mefedrone?
- Each substance has a full profile on this site with dosage, interactions, testing, and legal information. Follow the links at the bottom of this page.
- How do I test whether my substance is MDMA or Mefedrone?
- Reagent testing can distinguish most substances. Check the reagent guide tool for expected color reactions for both.