Reference · 2026
Substance interactions.
Pharmacology, concrete risks and harm-reduction for the 30 most-searched substance combinations. Each combo has its own page with mechanism notes, what to watch for, and what to do if you already mixed.
For arbitrary multi-substance combos use the interactive checker.
- DangerousCocaine + AlcoholMechanism, risks, harm reduction
- DangerousKetamine + AlcoholMechanism, risks, harm reduction
- DangerousXanax (Alprazolam) + AlcoholMechanism, risks, harm reduction
- DangerousXanax (Alprazolam) + OpioidyMechanism, risks, harm reduction
- DangerousValium (Diazepam) + AlcoholMechanism, risks, harm reduction
- DangerousGHB / GBL + AlcoholMechanism, risks, harm reduction
- DangerousGHB / GBL + KetamineMechanism, risks, harm reduction
- DangerousTramadol + AlcoholMechanism, risks, harm reduction
- DangerousTramadol + MDMAMechanism, risks, harm reduction
- UnsafeMDMA + AlcoholMechanism, risks, harm reduction
- UnsafeMDMA + CocaineMechanism, risks, harm reduction
- UnsafeAmphetamine + AlcoholMechanism, risks, harm reduction
- UnsafeMefedron + AlcoholMechanism, risks, harm reduction
- UnsafeMefedron + MDMAMechanism, risks, harm reduction
- UnsafeGHB / GBL + MDMAMechanism, risks, harm reduction
- CautionMDMA + CannabisMechanism, risks, harm reduction
- CautionMDMA + LSDMechanism, risks, harm reduction
- CautionMDMA + KetamineMechanism, risks, harm reduction
- CautionCocaine + CannabisMechanism, risks, harm reduction
- CautionCocaine + KetamineMechanism, risks, harm reduction
- CautionKetamine + MDMAMechanism, risks, harm reduction
- CautionLSD + AlcoholMechanism, risks, harm reduction
- CautionLSD + CannabisMechanism, risks, harm reduction
- CautionLSD + MDMAMechanism, risks, harm reduction
- CautionPsilocybin mushrooms + AlcoholMechanism, risks, harm reduction
- CautionPsilocybin mushrooms + CannabisMechanism, risks, harm reduction
- CautionAmphetamine + CannabisMechanism, risks, harm reduction
- Caution2C-B + MDMAMechanism, risks, harm reduction
- UnknownLSD + Psilocybin mushroomsMechanism, risks, harm reduction
- UnknownXanax (Alprazolam) + CocaineMechanism, risks, harm reduction