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Mefedrona dosage 2026: safe ranges by route and weight.

Mefedrona has 3 documented routes of administration. The most common is oral. Always start at the lowest dose range and wait the full onset window before redosing.

Dose ranges by route.

Oral
Limiar
50 mg
Leve
75–150 mg
Comum
150–225 mg
Forte
225–350 mg
Pesada
350 mg
Aspirado
Limiar
15 mg
Leve
30–60 mg
Comum
60–120 mg
Forte
120–175 mg
Pesada
175 mg
Retal
Limiar
30 mg
Leve
50–100 mg
Comum
100–175 mg
Forte
175–250 mg
Pesada
250 mg

Começa por baixo. Corpo, tolerância e misturas mudam tudo.

Duration timeline.

Oral

total ~ 510 min
Início: 30–60 minPico: 60–120 minDescida: 60–90 minRescaldo: 2–4h
Início
30–60 min
Pico
60–120 min
Descida
60–90 min
Rescaldo
2–4h

Aspirado

total ~ 405 min
Início: 5–15 minPico: 30–60 minDescida: 45–90 minRescaldo: 2–4h
Início
5–15 min
Pico
30–60 min
Descida
45–90 min
Rescaldo
2–4h

Retal

total ~ 475 min
Início: 10–25 minPico: 60–120 minDescida: 60–90 minRescaldo: 2–4h
Início
10–25 min
Pico
60–120 min
Descida
60–90 min
Rescaldo
2–4h

Bodyweight quick formula

For a 70 kg adult, divide the total mg dose by 70 to get your mg/kg ratio. Most published ranges assume this reference weight. If you weigh significantly less, reduce proportionally; significantly more does not always mean linearly higher doses.

Related pages


FAQ.

What is a safe Mefedrona dose?
A "safe" dose depends on body weight, tolerance, set and setting. Start at the threshold or light range for your chosen route and do not redose until onset is complete.
How do I calculate Mefedrona dose by weight?
For substances where bodyweight matters: divide the mg amount by your weight in kg to get the mg/kg ratio. Most common dose data assumes a 70–80 kg adult.
What happens if I take too much Mefedrona?
Exceeding the "heavy" range significantly increases risk of adverse effects, medical emergency, or overdose. Harm reduction starts with knowing the ranges.
How long does Mefedrona last?
Duration varies by route. The timeline section below shows onset, peak, offset and after-effects for each route.
Can I mix Mefedrona with other substances?
Many combinations are dangerous. Check the interaction checker tool before combining anything. Never combine on a first experience.
Is Mefedrona dosage the same for all routes?
No. Bioavailability differs significantly by route — intranasal and IV routes typically require lower doses than oral for equivalent effect.
Should I weigh my Mefedrona dose?
Always. A milligram scale (0.001g precision) is essential for most substances. Volumetric dosing with a solvent is the gold standard for sub-10mg doses.